DIETARY RESTRICTION

  • Nitisinone Tablets must be used in conjunction with a diet restricted in the amino acids tyrosine and phenylalanine.
  • Food to avoid include, fish, eggs, milk, meat, bread, cheese and nuts.
  • Treatment with Nitisinone Tablets and dietary management should begin as soon as possible after the diagnosis is confirmed.
  • A restricted diet alone is not effective in preventing liver, kidney, and neurologic problems associated with HT-1.

ENSURE HT-1 PATIENTS:

1-Maintain a low protein diet

2-Take Nitisinone Tablets as prescribed by their doctor

DISCLAIMER:
THIS INFORMATION DOES NOT PROVIDE MEDICAL ADVICE. All content (“Content”), including text, graphics, images and information are for general informational purposes only. You are encouraged to confer with your doctor or other health care professional with regard to information contained on this information sheet. After reading this information, you are encouraged to review the information carefully with your doctor or other healthcare provider. The Content is not intended to be a substitute for professional medical advice, diagnosis or treatment.

TOP 10 FOODS HIGHEST IN TYROSINE

milligrams of Tyrosine in 100 grams of food

CHEESE 1995mg/100g
SOY FOODS 1497mg/100g
LEAN BEEF & LAMB 1386mg /100g
LEAN PORK 1228mg /100g
FISH & SEAFOOD 1157mg/100g
CHICKEN & TURKEY 1155mg/100g
SEEDS & NUTS 1093mg/100g
EGGS & DAIRY 499mg/100g
BEANS & LENTILS 274mg/100g
WHOLEGRAINS 169mg/100g

INDICATION AND CLINICAL USE

Nitisinone Tablets are indicated for the treatment of hereditary tyrosinemia type 1 (HT-1) in combination with dietary restriction of tyrosine and phenylalanine.

Treatment with Nitisinone Tablets should be initiated and supervised by a physician experienced in the treatment of HT-1.

IMPORTANT INFORMATION ABOUT NITISINONE TABLETS

How do NITISINONE TABLETS work? NITISINONE TABLETS stop the build-up of toxic substances which cause the severe liver and kidney problems in patients with HT-1. By doing that, they also prevent the porphyric crises associated with HT-1.

What are the ingredients in NITISINONE TABLETS? 

  • Medicinal ingredients: Nitisinone
  • Non-medicinal ingredients: glyceryl dibehenate, lactose monohydrate.

Do not use NITISINONE TABLETS if you:

  • Are allergic (hypersensitive) to nitisinone or any of the other ingredients in NITISINONE TABLETS.
  • Are breast-feeding. Do not breast feed while taking NITISINONE TABLETS.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take NITISINONE TABLETS. Talk about any health conditions or problems you may have, including if you:

  • Are pregnant or planning to become pregnant.

How to take NITISINONE TABLETS

  • NITISINONE TABLETS are usually taken twice a day.
  • Swallow the tablets whole with a drink of water. NITISINONE TABLETS can be taken with or without food.
  • For more information on infant administration refer to the product monograph.

Overdose: If you think you have taken too many NITISINONE TABLETS, contact your healthcare professional, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms. If you go to a healthcare professional or to the hospital, take the NITISINONE TABLETS container with you.

Missed Dose: If you forget a dose, take the next dose as planned. Do not take a double dose to make up for a forgotten dose. If you forget to take a dose, contact your healthcare professional or pharmacist.

Storage:
Keep out of reach and sight of children. Store your tablets at room temperature (15 – 30°C), in a dry place. Keep the container tightly closed. There is an expiry date on the label. Do not use the medicine after this date.

PLEASE SEE PRODUCT MONOGRAPH
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